DICER1 and cancer: In parallel with the role of Dicer functioning as a haplo-insufficient tumor suppressor, recent studies also identified Dicer as a HIF-1α-interacting protein to promote CSC and metastatic activities in multiple types of cancer cell lines and human tumors, where HIF-1α suppresses Dicer expression by promoting its ubiquitination and autophagy-mediated degradation, leading to repressed maturation of known tumor suppressor miRNAs, including let-7 and miRNA-200b [52].