For example, treatment of pancreatic cancer cells with metformin, an antidiabetic drug, decreased the expression of the CSC markers CD44, EpCAM, EZH2, NOTCH1, NANOG and OCT4 but elevated the expression of miRNAs, including let-7a, let-7b, miR-26a, miR-101, miR-200b, and miR-200c in a mouse xenograft model [89]. The gene discussed is NOTCH1; the disease is familial pancreatic carcinoma.