Continued research on FGF19 as therapeutic agents resulted in the design of NGM282, which is also called Aldafermin, an engineered FGF19 analog that was used in phase 2 human safety and efficacy trials to treat patients diagnosed with non-alcoholic steatohepatitis (NASH) [33] (Table 1). The gene discussed is FGF19; the disease is metabolic dysfunction-associated steatohepatitis.