ERLIN2 and hereditary spastic paraplegia: Emerging studies on mutations in the ERLIN1 or ERLIN2 genes have related these variants to rare neurodegenerative diseases, e.g., hereditary spastic paraplegia (HSP) [126,127,128], a heterogeneous group of genetic neurodegenerative disorders (MND) characterized by progressive spasticity that primarily affects the lower extremities and afterwards it can extend cranially with progressive spasticity of the lower limbs [129].