Moreover, cholesterol depletion from lipid rafts in ovarian cancer cells, after increased cholesterol efflux due to specific transporters, is responsible for the phenotypic reprogramming of macrophages into tumor-associated macrophages, making them more responsive to pro-tumor signals, such as IL-4, and more resistant to the action of anti-tumor cytokines, such as interferon-gamma [53,54,55,56,57]. This evidence concerns the gene IL4 and neoplasm.