In a similar manner, mice intravenously injected with HO-1-overexpressed melanoma cells, namely B16-HO1, were characterized by augmented vascularization and a higher level of vascular endothelial growth factors in the tumor, whereas a lower level of serum TNF-α but a higher level of soluble receptor TNF-RI were observed. The gene discussed is HMOX1; the disease is melanoma.