Furthermore, the expression levels of p-mTOR, mTORC1, mTORC2, Akt, NF-κB, STAT3, and CDK6 in U251 and U87MG cells following treatment with the combined therapy of palbociclib: GBM-N019 were more significantly reduced compared to their expression levels in cells treated with individual drugs (Figure 7F). Here, STAT3 is linked to glioblastoma.