The phosphatidylinositol-4,5-biphosphate 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway has emerged as one of the most deregulated oncogenic pathways that contribute to aggressive phenotypes, drug resistance, and poor prognoses in GBM patients [7]. The gene discussed is PIK3CA; the disease is glioblastoma.