The PPI networks of mTOR, STAT3, and CDK6 were enriched in cancer-associated KEGG pathways and ontologies, among which cyclin-dependent protein serine/threonine kinase activity, transcription factor binding, mTOR signaling pathway, pancreatic cancer, non-small cell lung cancer, glioma, EGFR tyrosine kinase inhibitor resistance were those enriched (Figure 2F lower panel). Here, CDK6 is linked to central nervous system cancer.