Of these isoforms, the expression of PFKFB2 has been found to be transcriptionally upregulated by androgen receptor (AR) signaling in prostate cancer cells, involving downstream activation of the calcium-calmodulin/dependent protein kinase II (CAMKII)-AMPK signaling pathway, and also by direct recruitment of the ligand-activated androgen receptor to the PFKFB2 promoter [102]. Here, AR is linked to Familial prostate cancer.