In contrast, high KDM6A and KDM6B demethylase activity with correspondingly lower levels of H3K27 trimethylation were observed in posterior fossa A ependymomas, a rare paediatric tumour that strictly depends on hypoxia for survival and exhibits high levels of glycolysis, non-oxidative pentose phosphate and polyamine metabolism [121]. This evidence concerns the gene MBD2 and neoplasm.