Thus, 5’triphosphate dsRNA (3pdsRNA) encapsulated in lipid calcium phosphate nanoparticles, promoted antitumor over protumor TAMs, strong levels of pro-inflammatory Th1 cytokines, and increased the proportion of CD8 T cells over Treg cells, altogether leading to significant delay in pancreatic cancer growth [259]. Here, CD8A is linked to familial pancreatic carcinoma.