Multiple actions of macrophages in the TME, and in the regional lymph nodes, may positively accelerate each of the consecutive functional steps of the cancer-immunity cycle, including: (1) killing of cancer cells, (2) cancer cell antigen transfer to DCs, (3) T cell activation, (4) recruitment of circulating T cells to the tumor bed, (5) facilitating T cell infiltration within the tumor and (6) promoting the killing of tumor cells by NK and CD8 T cells (Figure 1). Here, CD8A is linked to cancer.