Similarly, blocking microsomal prostaglandin E synthase-1 (mPGES-1) activity with compound III (a benzoimidazole) impaired angiogenesis, inhibited cancer-associated fibroblast accumulation, reduced tumor cell proliferation and favored a shift in the antitumor/protumor macrophage ratio, consequently reducing tumor growth [221]. Here, PTGES is linked to neoplasm.