These findings underscore the significance of TAMs as important components of the CSC niche, thus targeting TAMs by inhibiting their receptor such as the myeloid cell receptors colony-stimulating factor-1 receptor (CSF1R) or the chemokine (C-C motif) receptor 2 (CCR2), which decreases the number of TICs, improves chemotherapy outcome and elicits anti-tumor T cell responses [86]. This evidence concerns the gene CCR2 and neoplasm.