Similarly, CSCs from CRC, HNSCC and GBM were found to release immunosuppressive cytokines, encompassing IL-4, IL-8, granulocyte-CSF, MΦ inhibitory cytokine-1 (MIC-1) and TGF-β, that impair the cytotoxic T lymphocyte (CTL) function [29]. Here, TGFB1 is linked to colorectal carcinoma.