CD274 and glioblastoma: In an orthotopic mouse model of glioma, the combinatorial administration of a vaccine (containing GBM stem cell lysate, DCs and TLR-9 agonist CpG motif-containing oligodeoxynucleotides (CpG ODNs)) and the anti-PD-L1 antibody confers a greater survival advantage and decrement of the Treg fraction as compared to the vaccine alone [171].