The authors also showed that nuclear TFEB favored lysosomal-exocytosis-mediated IL-β secretion, a pro-inflammatory cytokine that has been related to impair insulin secretion and shown to contribute to chronic inflammation reported in type 2 diabetes mellitus patients [78,79], strengthening the idea that although there is evidence that TFEB activation can promote a response that helps the cell to deal with stress, under specific circumstances it could trigger detrimental effects. Here, TFEB is linked to type 2 diabetes mellitus.