PLEC and epidermolysis bullosa simplex: Then again, rodless mutation encoded by a nonsense mutation in PLEC exon 31 and an identical frameshift mutation in exon 32 in two patients with epidermolysis bullosa simplex (EBS) with a myasthenic syndrome (EBS-Mys) still showed a severe phenotype, which could not be explained solely by the rodless versus full transcript ratio when compared with control subjects, although a higher ratio was detected in the more affected patient [27].