To date, cancer-associated IDH1/2 mutations are commonly found in acute myeloid leukemia (~20%) [24], melanoma [25], cartilaginous tumors (56–70%) [26], cholangiocarcinoma (8.5–20%) [27], and WHO II/III gliomas (~80%) [3,28]. The gene discussed is IDH1; the disease is acute myeloid leukemia.