Sun et al. also demonstrated that in the IDH1 knock-in mice model, U87 glioma cell line, and clinical databases, angiogenesis-related factors, including ANGPT1, PDGFB, and VEGFA, were downregulated in the IDH-mutated gliomas group, and promoter regions were also highly hyper-methylated [90]. Here, IDH2 is linked to central nervous system cancer.