Here, we proved the effect of GDF-15 of autophagy by using, in vitro, a human atherosclerosis MΦ model and in vivo GDF-15-deficient (GDF-15−/−) mice within an experimental atherosclerosis apolipoprotein (apo)E knockout (ApoE−/−) mouse model. This evidence concerns the gene GDF15 and atherosclerosis.