CHI3L1 and Alzheimer disease: Therefore, current efforts are moving towards specific markers of microglial/astroglial activation, such as YKL-40 (also known as chitinase-3-like protein), a tracking biomarker of astroglial-related neuroinflammation, which is increased in CSF of AD patients contributing to differentiate AD from non-AD pathologies [34,35], see Table 2.