Research over the last few decades has led to the discovery of some risk factors, including non-modifiable genetic factors (AD-related polymorphisms, APO-E4 allele, and pathogenic mutations in PSN-1-2 and APP genes) [2,3] and modifiable factors (favorable behaviors: regular physical and mental activity, healthy diet, high education and social engagement, and harmful conditions: midlife obesity, hypertension, diabetes, smoke, excessive alcohol and hearing loss) [4,5]. This evidence concerns the gene APP and Alzheimer disease.