Knockdown of caveolin-1 and cavin (caveolin-1 expression and cavin stability regulate caveolae dynamics) in GBM U251 cells decreased expression of matrix metalloproteinases (MMPs), epithelial mesenchymal markers, and epithelial–mesenchymal transition (EMT) markers and inhibited cell invasion [78]. The gene discussed is CAVIN1; the disease is glioblastoma.