ATG7 and glioblastoma: In contrast, another study reports that ATG5 and ATG7, both of which are autophagy related genes, are important for cell death in GBM while CRISPR-Cas9 mediated knockout of ATG5 and ATG7 in GBM MZ-54 cells protect the cells from cell death when compared with control cells in response to various autophagy inducers (loperamide, pimozide, and STF-62247) [57].