At least, it is noteworthy that hematopoietic differentiation of JMML IPSC modeled characteristic features of JMML (such as GM-CSF-hypersensitive progenitor cells and expansion of the myeloid lineage) irrespective of whether IPSC were derived from BM/PB [18,20,21] or fibroblasts [19,22]. The gene discussed is CSF2; the disease is juvenile myelomonocytic leukemia.