The most common morphological and biochemical parameters include lymphopenia, neutrophilia, an elevated neutrophil to lymphocyte ratio (NLR), D-dimer concentrations, level of inflammation marker C Reactive Protein (CRP), lactate dehydrogenase (LDH), or an elevated reactive lymphocyte (RE-LYMP) parameter, in addition to cytokine release syndrome [3,4,5,6]. Here, CRP is linked to Down syndrome.