In obesity and obesity-related disorders, such as diabetes, the key actors in the systemic chronic inflammation are the incrementing of pro-inflammatory macrophages and the release of uncontrolled cytokines and hormones, such as MCP-1, IL-6, IL-1β and TNF-α, but also leptin and adiponectin, by the adipose tissue [17,38]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.