STAT1 and Alzheimer disease: Similarly, sFgl2-AD-MSCs promoted M2 polarization in vitro, especially in a proinflammatory environment with IFN-γ/lipopolysaccharide (LPS) treatment, through the inhibition of the signal transducer and activator of transcription 1 (STAT1) and nuclear factor-κB (NF-κB) pathways.