Since macrophage infiltration in the liver of treated woodchucks was also reduced, these results are in agreement with the reported anti-inflammatory properties of hzVSF in regard to treatment of severe COVID-19 symptoms that led to a marked decline in the serum levels of C-reactive protein, interleukin 6, tumor necrosis factor-α, and CC chemokine ligand-2 or monocyte chemoattractant protein 1 [37]. This evidence concerns the gene TNF and COVID-19.