Telomerase reverse transcriptase (TERT) promoter mutations frequently occur in melanoma and, according to The Cancer Genome Atlas (TCGA) data, mainly in the mutated subtypes BRAF (75% of cases), RAS (72% of cases), and NF1 (83% of cases), suggesting a link between MAPK activation and TERT expression. This evidence concerns the gene NF1 and melanoma.