Additionally, in MF the infection-driven response of circulating monocytes is defective since monocytes from JAK2V617F-mutated patients show an altered expression of chemokine C-C chemokine receptor type 2 (CCR2), C-X-C motif chemokine receptor 3 (CXCR3), CCR5 and cytokine (TNF-α-R, IL-10-R, IL-1β-R, IL-6-R) receptors. This evidence concerns the gene CCR2 and infection.