However, inhibition of Nox2 with gp91dstat, whilst also reducing pulmonary EC O2•− reduced aortic atherosclerosis and elastin fragmentation in ESMIRO/ApoE−/− mice [18] Once again, it is clear that the relationship between insulin resistance and Nox2 dependent O2•− release is far from linear. The gene discussed is CYBB; the disease is Insulin resistance.