CYBB and Insulin resistance: Basal production of O2•− within pulmonary EC of ESMIRO/Nox2y/− mice was reduced compared to that of ESMIRO mice alone, highlighting that Nox2 is a vital intermediary in the production of ROS in insulin resistance, and confirming that there is no adequate compensatory mechanism for increasing ROS production in the setting of insulin resistance if Nox2 is deficient [16].