In this context, estradiol down regulated: ZFYVE16, a FYVE zink finger family protein (also called endofin) that regulates cell adhesion and induces cell migration [46] by regulating TGFβ signaling pathway and is downregulated by ER-β in cancer cells [47]; and epiregulin, which stimulates cell migration via MAPK activation [57]. The gene discussed is ESR2; the disease is cancer.