Indeed, different NOX subunits, including p47phox, p67phox, and Rac1, were found increased in pre-neoplastic and neoplastic lesions from c-Myc, TGF-β, and c-Myc/TGF-β transgenic mice, where HCC developed under a context of high ROS content and decreased antioxidants in hepatocytes [145]. Here, MYC is linked to hepatocellular carcinoma.