Indeed, different NOX subunits, including p47phox, p67phox, and Rac1, were found increased in pre-neoplastic and neoplastic lesions from c-Myc, TGF-β, and c-Myc/TGF-β transgenic mice, where HCC developed under a context of high ROS content and decreased antioxidants in hepatocytes [145]. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.