The ability of Nogo-A to modulate neuronal excitability as well as pCREB and c-Fos levels makes it extremely interesting in the context of research addressing the molecular mechanisms regulating learning and memory processes, and particularly the formation of memory engrams in healthy and pathological conditions, like the implementation of unwanted memories in post-traumatic-stress-disorder. The gene discussed is FOS; the disease is post-traumatic stress disorder.