VWF and obesity due to melanocortin 4 receptor deficiency: These metabolic observations of aging and obesity were exacerbated in COVID-19 patients and were consistent with disease severity, as indicated by clinical records and clinical measurements of markers of inflammation (IL-6, CRP), coagulopathy (D-dimers, APTT, INR, FVIII, VWF:AG, VWF:collagen-binding activity, VWF:ADAMTS-13 activity ratios, thrombin and plasmin generation), and renal dysfunction (BUN, creatinine).