Aging was associated with increased weight, BMI, kidney dysfunction (creatine, creatinine), and tissue damage (creatine kinase), along with markers of hypercoagulability (VWF:AG, FVIII), fibrinolysis (D-dimer), hyperglycemia, hypoxia and mitochondrial dysfunction (2-hydroxyglutarate, lactate, spermidine, acylcarnitines), purine oxidation (urate), inflammation (CRP), proteolysis (albumin), and anemia (hemoglobin levels, RBC counts), especially in COVID-19 patients (Figure 3A–D). The gene discussed is VWF; the disease is anemia (phenotype).