Taken together, the molecular actions relevant for bortezomib induced cell death of MM cells might include blocking pro-survival pathways of WNT/β-catenin and EGFR and activating p53-mediated cell cycle arrest and apoptosis; however, in the case of fatty acids, DHA/EPA might inhibit ERK, JNK, and EGFR signaling pathways and activate PTEN and p53 signaling pathways, autophagy, ferroptosis, and necroptosis. This evidence concerns the gene PTEN and Miyoshi myopathy.