The heatmap showed that 12 tumor suppressors formed into two clusters: cluster 1 contains seven downregulated tumor suppressors including PTEN, PSME1, DNAJB1, HSPH1, DEDD2, PAK1IP1, and MIR1244-3; and cluster 2 contains five upregulated tumor suppressors (OSGIN1, IFI27L1, MTCH2, NKD2, and IBTK) (Figure 2E). This evidence concerns the gene IBTK and neoplasm.