Altogether, the above results revealed that cellular pathways of necroptosis, ferroptosis, p53, NRF2, ATF4, WNT, p38-MAPK, NF-κB, and EGFR might be involved in bortezomib chemosensitivity in MM cells increased by DHA/EPA pretreatment. Here, NFE2L2 is linked to Miyoshi myopathy.