Among them, adiponectin (Acrp30) has been demonstrated to be not only related to metabolic diseases, such as obesity, type 2 diabetes mellitus, and obstructive sleep apnea syndrome, but also involved in the regulation of immune response, such as rheumatoid arthritis and systemic lupus erythematosus [35,36,37]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.