Levels of inhibitory receptors PD-1, LAG-3/CD223 (lymphocyte activation gene 3 product), TIGIT (T cell immunoreceptor with immunoglobulin and ITIM domain), and ectonucleotidase CD39, combined with T-cell hyporesponsiveness of tumor-specific T cells, suggest poor function of tumor infiltrating lymphocytes (TILs) and confirm severe exhaustion observed in GBM [90]. The gene discussed is LAG3; the disease is neoplasm.