Along with tumor-associated macrophages (TAMs), microglia largely contribute to immunosuppression through the interaction and synergistic release of soluble factors such as granulocyte-macrophage colony-stimulating factor (GM-CSF), C-X3-C Motif Chemokine Ligand 1, (CX3CL1), and SDF1 [35]. This evidence concerns the gene CSF2 and neoplasm.