Mechanistically, they proved that FTO-deficiency increases m6A-methylation at 5′UTR and 3′UTR of target genes; PD-1 (PDCD1), CXCR4 and SOX10, and thereby causing rapid mRNA-degradation by recruiting YTHDF2-reader proteins [155,157,158], confirmed by YTHDF2-knockdown in ‘increasing’ and YTHDF2-overexpression in ‘decreasing’ melanoma growth. This evidence concerns the gene YTHDF2 and melanoma.