CTLA4 and melanoma: However the first anti-CTLA4-based therapy ‘Ipilimumab’ was approved in 2011 by (James P. Allison, Nobel laureate, physiology or medicine, 2018) Medarex and Bristol-Myers Squibb for the treatment of melanoma, and the first anti-PD-1 therapy was approved in 2014 for melanoma and in 2015 for non-small-cell lung carcinoma (NSCLC) treatment (Table 2).