In addition, abnormal macrophage polarization characterized by increased M1-pro-inflammatory/anti-tumor (CD11b+F4/80+NOS2highIL-12high) and decreased M2-anti-inflammatory/pro-tumor (CD11b+F4/80+ARG1highIL-10high) were also noted in Mettl3cKO mice, along with impaired response to effector T-cell functions. This evidence concerns the gene ITGAM and neoplasm.