More importantly, the flow cytometry analysis of tumor bearing mice (TBM) revealed increased infiltration of immunosuppressive cells like, regulatory T-cells (T-reg: CD4+CD25+Foxp3+) and myeloid derived suppressor cells (MDSCs: CD11b+Gr1+) in the TME evidenced by increased expression of CCL22-migratory marker in Mettl3cKO mice. The gene discussed is FOXP3; the disease is neoplasm.