Notably, aggregation and phosphorylation of p62 were identified in a wide range of neurodegenerative diseases, including neurofibrillary tangles in AD [109], SOD1 aggregates in ALS [110], ubiquitin inclusions in PD, Lewy bodies in dementia [111], and huntingtin inclusion in HD [112]. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.