PLEC and acute myeloid leukemia: Interestingly, in a genome-wide analysis of bone marrow mesenchymal stromal cells (BM-MSCs), a major component of the BM niche, derived from AML patients, found only a non-synonymous alteration in the plectin gene (R1801Q) to be mutated at diagnosis, complete remission, and relapse of the same patient [93].