Over the past decade, since first being revealed as a pancreatic cancer biomarker, our understanding of plectin has dramatically evolved, expanding its application as a potential biomarker to multiple cancers and leading to the development of plectin and CSP-targeted imaging and drug delivery modalities, elucidation of its various roles in cancer progression, and the design of anti-plectin therapies with potent anti-cancer effects. Here, PLEC is linked to familial pancreatic carcinoma.