Unlike SLFN5, SLFN11 expression is reduced in renal tumors compared to the adjacent non-tumorous tissue in both papillary renal cell carcinoma and chromophobe renal cell carcinoma [64], raising the possibility that SLFN11 downregulation may contribute to tumorigenesis in both papillary and chromophobe RCC. Here, SLFN5 is linked to chromophobe renal cell carcinoma.