Although normal human gastric mucosa has been reported to express minimal or no SLFN5 protein [49,85], SLFN5 expression is upregulated in patients with atrophic gastritis, both intestinal and diffuse subtypes of gastric carcinoma, and in intestinal metaplasia that has progressed to gastric cancer [16]. The gene discussed is SLFN5; the disease is chronic atrophic gastritis.