L-02 normal liver cells have higher SLFN11 expression than HCC cell lines, and overexpressing SLFN11 in HCC cell lines (HCCLM3, Hep3B, SMMC-7721, and PLC/PRF/5) inhibits cell proliferation, migration/invasion, induces apoptosis, and reduces HCC growth and metastasis in vivo. The gene discussed is SLFN11; the disease is hepatocellular carcinoma.