Unlike SLFN5, SLFN11 expression is reduced in renal tumors compared to the adjacent non-tumorous tissue in both papillary renal cell carcinoma and chromophobe renal cell carcinoma [64], raising the possibility that SLFN11 downregulation may contribute to tumorigenesis in both papillary and chromophobe RCC. This evidence concerns the gene SLFN11 and papillary renal cell carcinoma.