In vitro, overexpressing SLFN12 in lung adenocarcinoma cells reduces proliferation by inhibiting c-myc translation, with no similar effect on c-myc or cell proliferation in lung adenocarcinoma cells [15], demonstrating a specific SLFN12 effect in one distinct subtype of lung cancer (lung adenocarcinoma). Here, SLFN12 is linked to lung carcinoma.