At the level of the genome, previous research has identified multiple common genetic mutations of NF-PitNETs, such as the activated mutations of GNAS, which have been found to be related to the pathogenesis of GH-PAs, while USP8 mutations were involved in 11 out of 20 ACTH-PAs [13,14,15]. The gene discussed is POMC; the disease is gonorrhea.