Because no experimental model exists to study leprosy, or to evaluate T1R, we attempted to investigate whether differentiated THP-1 macrophages stimulated with M. leprae in the presence of IFN-γ could mimic the process observed in skin tissue/cells during T1R, while also assessing the impact of IFN-γ treatment on autophagy modulation. This evidence concerns the gene IFNG and leprosy.