Hyperphosphorylation of the tau protein after ischemic brain injury [48,49,60,62,63,64,65,70,71,79,80] triggers the development of neurofibrillary tangles [63,70,71], which are one of the major components of pathology in the brains of Alzheimer’s disease patients. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.