MAPT and early-onset autosomal dominant Alzheimer disease: Previous research has shown that a decrease in the tau protein is correlated with an increase in an autophagy marker such as microtubule-associated protein 1A/1B-light chain 3B-II in a 3xTg mouse model of Alzheimer’s disease after reversible hypoperfusion, indicating that autophagy may be a way to reduce the dysfunctional tau protein levels in the brain [126].