To test whether PIK3CA, SLC6A6, TMEM-43, and ASAP-1 expression is driven by CLDN1 and CLDN7 expression, we analyzed these genes and proteins in CLDN1-overexpressing SW480 (SW480CLDN1) and CLDN7-knockdown DLD-1 (DLDCLDN7KD) colon cancer cell lines. The gene discussed is PIK3CA; the disease is malignant colon neoplasm.