However, as shown in Figure 6, TGFBR2 promoter hypermethylation in HCC is significantly associated with high tumor grade and metastasis (p < 0.001) and to a lesser extend with lower alfa fetoprotein level (p = 0.029) but no significant correlation is found with recurrence. This evidence concerns the gene TGFBR2 and hepatocellular carcinoma.