The group then investigated the effects of overexpression of miR-31-3p in a DSS-induced colitis model by intracolonic administration of agomirs (dose: 80 μg) and found it to alleviate colitis as seen by the reduction in colonic immune cell infiltration, TNFα, CXCL10 and CCL2 mRNA, and improvement in the histopathology score. Here, CCL2 is linked to colitis.