By gene expression and promoter analysis coupled with protein–DNA interaction assay in HCC, we did find that FN, LEF, COX2, and COL1A1 were transcriptionally upregulated by SNA via binding to the proposed SNA binding motifs, which are close to the EGR-1/SP1 overlapping regions. The gene discussed is COL1A1; the disease is hepatocellular carcinoma.