Thus, it is tempting to investigate whether SNA can directly activate transcriptional upregulation of other EMT-related genes involved in HCC progression such as FN [19], LEF [20], COX2 [21,22,23], and COL1A1 [24,25,26] in a similar fashion as observed in MMP9 and ZEB1. This evidence concerns the gene PTGS2 and hepatocellular carcinoma.