In addition to novel histological features [15,16] and morphology-based immune contexture parameters [17], recent meta-analysis showed that, in OSCC, a favorable overall outcome is associated with a high density of tumor infiltrating lymphocytes (TIL) as NK-cells, CD45RO+ T-cells and CD8+ T-cells, mainly if measured in the tumoral site [18,19], whereas tumor-associated CD68+ or CD163+ macrophages predict a worse prognosis [19]. The gene discussed is CD163; the disease is neoplasm.