CD8A and neoplasm: Analyzing both the center of the tumor (CT) and the invasive margin (IM), the latter was significantly enriched (p < 0.0001) of CD8+ T-cells (median 394 cells/mm2, IQR 210–712) compared to the CT (median 170 cells/mm2, IQR 64–430), as shown in Figure 1G; furthermore, a strong direct correlation between the density of CD8 T-cells in CT and IM was evident (R = 0.78 (CI95% 0.71–0.83, p < 0.0001, Figure 1H)); representative fields of the analysis are shown in Figure 1.