FKBP5 and major depressive disorder: In fact, in a search carried out on treatments for depression and post-traumatic stress disorder, it was found that through a screening of 1280 pharmacologically active compounds, three compounds were responsible for attenuating FKBP51-mediated suppression of GR and one disrupted the association of FKBP51 with the GR/Hsp90 [48].