Indeed, it is known that Ang-1 and Tie-2 play a key role in: (1) regulating new vessel formation in the developing heart [33]; (2) promoting cardiac and skeletal survival via integrins [33]; (3) reducing myocardial apoptosis [34]; and (4) promoting progenitor CD133+/c-kit+ cells, which facilitate myocardial healing following infarction [35]. The gene discussed is TEK; the disease is infarction.