UBD and cancer: Table 2 summarises the findings that identified NUB1 and FAT10 as prognostic and predictive biomarkers. Although the concentration of NUB1 mRNA is higher in cancer cells, the depletion of NUB1 protein could lead to G0/G1 cell cycle arrest in vitro. The knockdown of NUB1 prevents the growth of MDA-MB-231 cell lines in vitro. The cell cycle arrests lead to the death of the breast cancer cells because of the accumulation of p21/p27 proteins in NUB1-depleted cells [69].