However, both IFN-β production and STAT1 activation are impaired by the depletion of RIG-I, leading to the hypothesis that the depletion of hMENA11a, that induces a deep rearrangement of the actin cytoskeleton, might activate the actin associated viral sensor RIG-I, mimicking a viral infection (manuscript in preparation), again supporting the link between actin cytoskeleton, RIG-I, and IFN-I signaling. Here, RIGI is linked to viral infectious disease.