Among the 30 detected proteins that were differently expressed in DOX-Ar-CC-NPs treated cells, pyruvate kinase, ATP synthase, enolase, glyceraldehyde-3-phosphate dehydrogenase, mitochondrial ADP/ATP carrier, and trypsin are the key enzymes engaged in energy metabolism, suggesting that far more energy must be employed by glycolysis to support tumour cells survive during subjected to chemical stress,. Here, GAPDH is linked to neoplasm.