NLRP3 and Cowden disease: In a prospective study of Cosin–Roger and colleagues [2], short-term environmental hypoxia exposure had a protective effect on acute colitis through NLRP3/mTOR downregulation and autophagy activation while lower levels of proinflammatory cytokines and chemokines were detected in colonic biopsies from CD patients after 3 h in a hypobaric pressure chamber [2].