No significant differences in immune cell nor proinflammatory gene expression profile could be identified between Phd1f/fVav:cre+/− TNFΔARE/+ and Phd1f/fVav:cre−/− TNFΔARE/+ mice (Figure S14 and Figure 7, respectively), indicating that hypoxia-induced signalling, as a result of Phd1-deletion, does not have an effect on ileitis initiation and progression. Here, EGLN2 is linked to Crohn ileitis.