Although pathology laboratories are diverse in terms of the amount of immunohistchemical markers available for diagnostic purposes, the most commonly employed markers in the context of diagnosing a neuroendocrine tumor (NET) constitute Chromogranin A (CGA), Synaptophysin (SYP), Cluster of differentiation 56 (CD56) and Neuron-specific enolase (NSE). Here, ENO2 is linked to neuroendocrine neoplasm.