In T2D patients with CAD, FPG (ap = 0.007; bp = 0.012), FPI (ap = 0.045), DPP4i (ap < 0.001; bp < 0.001), SU + DPP4i (ap = 0.011; bp = 0.016), biguanide + DPP4i + insulin (ap < 0.001; bp = 0.003), fibrates (bp < 0.001), statins (bp = 0.018), ACEI (ap = 0.032; bp = 0.029), alpha blockers (ap = 0.008; bp = 0.020), and hematinic agents (ap = 0.011; bp = 0.016) were significantly associated with the severity of CAD. This evidence concerns the gene INS and type 2 diabetes mellitus.